Omega-3 in heart disease; the original story from the source

ABOUT THIS EPISODE

"Dr. Jorn Dyerberg tells the story of discovering the role of omega-3s in human health. It’s his story to tell. More than 50 years ago as a young medical student, Dr. Dyerberg and his mentor set out to understand how Greenland Inuits could have such a low rate of heart disease while living on a high fat diet. A sense of adventure, sled dogs, seal blubber, scientific methods, commitment to publish, and collaboration are all part of the story that launched the science of marine-sourced omega-3s. 

Topics Discussed:

5:40 Dr. Dyerberg's journey to Greenland 

8:24 Research that contributed to Dr. Dyerberg and Dr. Bang's omega-3 discovery 

11:08 Omega-6 research on blood clotting tendencies 

17:26 Medical research acceptance and clinical trials on omega-3s 

19:43 Clarifying comments on bleeding tendencies 

26:33 Closing thoughts on life's research & omega-3 deficiencies  

Resources Mentioned in this episode:

Dr. Jorn Dyerberg Bio 

Bang and Dyerberg's omega-3 discovery turns fifty  

https://pubmed.ncbi.nlm.nih.gov/1163480/ "

By this, the log chain on we get free,fadists were introduced into human nutrition, research, science and alsointo human fruit, because from that arm, which took rather many years, it wasbrought out so that today we realized that first of all, the long chantingwith a free year, headiest have a dot of our chemical effect in our body andare essential for healthy life. Hello and welcome to the science andthe story behind Omega three, a podcast brought to you by wily companies wherewe explore one of the most research nutrients on the planet, listen in asGlobal Omega. Three experts and researchers translate the science,reveal personal insights and share their stories of discovery whilenavigating the Sea of Omega Three Science. Thanks for joining us today. Now here'syour host Greg Lindsay Welcome back to another episode of theScience and the story behind Omega three, where we talk with experts fromall over the world, our guests to day is considered by many to be the fatherof a megatheres, his pioneering discovery, a marine source to make athrees and human heart health set the trajectory now. Fifty Years of clinicalwork with the mega three fats, he is professor, a Meritis at the Universityof Copenhagen having been awarded the Living Legend Award by theInternational Union of nutrition scientist, he is truly a living legend.We are thrilled to welcome to the program Dr Yorn direr welcome, Doctor Yerburg, and thank youso much for being here today. Your ground breaking work has been anextraordinary contribution to the field of a Maka three research. We areexcited to hear where the science and the story behind Omega threes began. Dr Diber, I recently saw a letter tothe editor in nature that paid tribute to your discovery in first publicationin one thousand nine hundred and seventy one, which was fifty years agothis year, the results every research were published in one thousand ninehundred and seventy one. So obviously the story started well before then I'll,probably ask for questions that I typically do on this program, because Iwant to sit back and hear the story of how and where it began and hear aboutyour journey. Okay, yeah. What I hear about my own, we get free. Fides is, ofcourse, it's a bit ridiculous for for me to say my sis, because I was not theguy that first saw them that we had something like long chain on with reFanny, as is in the nature in Ogwood, but I happen to have the privilege tobe one of the two that introduced the concept of long chain bullion andgraded falys in Julian nutrition and their meaning or effects, and it allstarted way way. Back more than fifty years ago I was a young doctor on thetraining as an internist and Inter medicine, and I spent years on internalmedicine departments that adds to supplement with Pidati o your neurologyyear and then half a year on a deponent clinical chemistry, and I appointed achief there door back and he was interested in cornerhouse and BlackLivid, and I got interest in that too and started my thesis work on a newmethod for determining life for proteins in blood. I mean a brand newmethod and it was mobile, basically...

...like Prodis was determined by Altrosenfication, which needed huge technical apparatus, and things like that. But Imade a new merfort that could determine liver, proteins and passmen, and byworking at that, suddenly in May one thousand nine hundred and sixtynine. There was a lead article in our Danish chaotical medical period, aweekly periodical saying that we should look at our coach citizens in Greenlandbecause green and was at that time, a part ofDenmark. But now it's a sort of Commonwealth relationship. But at thattime it was Denmark and the Innis of the Eskimos living up. There hadanother decease Peden and among the things that were strange, they rode inthis a editorial was that they had a low incident of corner heart disease asfar as they knew could find out in spite of living on a diet that wastraditionally very high and fat because they live from seal and sea of blumberand ferry fish, and the only thing at that time way back in the S H S, weknew about risk factors for corner artises was hivite died, will increaseyour cholesterol and increase cholesterol, will incase your risk ofgene corner so door Ben, come to my office and said Doctor Dibert that timewe were not on first names, and we were more formal that that this new methodwe have to go to green and in the excavating, the ESKIMOS and find outhow come that they don't have coryatides to the tic sense, as we havefound here in spite of a high fat diet. They are easy and, of course, a youngdoctor in his late twenties, having the opportunity of seeing the opportunityto go to greenland and do dog ledging on ice, and over I mean that wasscience. But that was far more. The experience, maybe that that caught me- and I said, of course, let'stry. If we can crash some money for that and we manage with out the banks,help to collect- I guess six thousand dollars or something for three personsto go to greenland for a month and a half living up there flying up to themain American soon as on to a airport and being taken by bold off the coastand landing in Mah the heart mountain area and set them down and got in contact withthe nurses and the doctors up there and managed over a month to travel from onesettlement of in its Eskimos to the other, consisting of fifty two hundredpersons living on remote islands, with their enormous amounts of docks forthis ledging and living from fish in sea. Lecordier, the immense ocean ofsurrounding them, and we managed to take blood samples from one hundred andthirty in its or Eskimos. At that time we always call the esquimos today. Thisword has got some sort of a Nigeta flavor. I don't know quite why, but it is so so,even if we at that time said Esquimos, which I think is- and you know itworked for people living from raw mead or something yeah to Innis, which is asort of cone, polar determination of the innuit people and we managed to getone of twenty sens of fasting blood...

...from in its Eskimos living in remoteareas of Reelin in their original way, not from western Diabe from Sealandrobber and fish and whatever shot and waves and whatever you can think of,and we came back home and we dihami their lipets and life of proteins andpublished in one thousand nine hundred and seventy one. The work that naturelater refers to the first one about broad livid on blood place, meliaporproteins in Eskimos, and we found that their blood cholesterol was low. TheDanes, but not to that extent, that it could explain their nearly nonexistence which what we found out by looking through Jones and see at thehospitals, and that the doctors in in main and net not enough to explain thedifference. So we actually in this paper, haspreferred to in nature pable. Today I said he there needs some extraexplanations and then comes that doctor Ben had anown gas COMATA that could determine plamate assets so wet. This started outon the two year journey of determining the faddy acid profile of the onehundred and twenty serals from fasting Eskimos that we have too simple toexham the Faddy, as is not because you had any suspicion that this was give usan explanation, but because we felt that we had the obligation to publishourselves wich cause, no one would ever be able to collect from genuine ESKIMO.So in its fasting symbols, and so whatever we could examine. We shout andpublish, and then we published that the faddist paint pattern of plasmatic inGreen and Escia the American journal with clen nutrition. A few years later,and among these there were two we had never seen before, and I went to homelie the net Brefhomeand at the man at that time, who knew about fades and he said Jon thesetwo family assets are, I cuerpo acid and do cue. They say Noyes ID and I Isaid again- and I learned to express these two strange names which today isnearly each housewife and knows because she has to be sure that her baby orkids get in off the H D and Her husband get it in our PA and whatever. But I'venever heard about it before and when nobody had been interested in them inrespect of human nutrition and risk a corner, artery disease and then camesome new results coming up in the laps of where you published the first paperfrom a group of Swedes Researches and British researches main and the holdingand whatever and saying that in the blot the Oman as six faddy acid,aric, hedonic acid, not Awori, ber ous, six Arcioni can give rise to proselandings that regulates blot clotting. They found some prose lange thatpromoted black clay and they found some present and in that inhibited, clockcabby, and there was a sort of balance from this on Gessi arician. I guess itthat has twenty Carmela sons and four double bons, that regulated blockclouding tendency and suddenly we got the idea of what, if the owl as sixfamily, especially PA, had another...

...balance between promoters of clothingand inhibitant, and we started with that and I got in concent with DoctorWayne and welcomes in Britain- and I remember I was over there for a meetingand I was young student and I called Professor Wain at his institute andfinally, a Secretaire said Doctor Way. You can give you five minutes. Okay, Isal. I have to really give him because he was the king of that and then Istarted talking and half an hour later. John said to me your way, shout I'msitting in the hotel in central I'm sending a cabin and getting you out tome, and then he sent a cabin and I was taken out to welcome her serve andBaganam, and we started a co work that ended up with a paper in the lands isshowing that from ICOSAHEDRON get formed in your bloot prosternit thathad another balance towards clouding tendency in favor of not craning and aVeree. My common function, a corner is a block clowning in the corneryutterlie. So if they died high in these two new fannys, it had an other Pattenthat favored a decrease in love, carding tendency. They would have twosymptoms, a bleeding tendency and a lower incidents of black clothing forexam. My car in faction, so the next expedition with Bang and I on our cobs-was the green and to examine the block citing tendency and Eskimos, and wemessage blot clothing, button and bleeding time by making small incisionsin their arms on the control condition and with the blinding people masteringthe seconds he took until the breathing stops. And then we read the legitur an.I was well known that Gregree and es and ISKIES o any Ich on expedition,have a tendency to nothe and and research is going up there for half ayear and more and doing each petition to the northern part of Greenland andnorthern part of Canada when living on Skoendal the same a block, clothing,Lowerin, bleeding tendency, and we published the paper in the Lance aboutFelateas, its and Bottardi tendency and dinner in ice compared to westernizepeople. We of course Cho stains and this paper boom open the old sow at atWiskars, the next two or three months. This was the issue that we wasdiscussed at the nutrition meetings and by this the longchain on a free Fatassi were introduced into human nutrition, research, science and also into humanfood. Because from that arm, which took rather many years, it was brought outso that today we realized that first of all, the long change with a free orvedia have a dot of our chemical effect in our body and are essential forhealthy life and a deficiency which I think we have in the West and were not.I think which we have in the Western world gives rise to deficiency symptomswhich can be or is...

...higher tendency of Cortina disease, butalso a high and flamatory intendency by rheumatism and things like that andfurther on to a long serious of effect that we have realized over these. Let'ssay forty years, a won the Freder, because the first paper just dealt withplasmatics and then it came gradually and have now deducted that the long change of tothink that as and then in particular Dha dos, a Nogat and Eva, I cosein e.no gas plays a huge amount of road, like the Ugashi t, the riveters, butmodulating and balancing the effect of the maybe over eating of the long chain,or we get six vedia that Western communities tend to live under. That was fifty years of science andliving in experience boiled down to in is so of too many words. Maybe no Dr Dibe. I don't think it was toomany words at all, although I am curious at that time, how did othermedical researchers except your findings e? They were first Ridiculi and andthen suddenly there came substance and then they came clinie trials. The firstmajor one was a gizzy study which was published in eighteen, nine. On my birthday, the isof September. Finding that giving a group of personswho had had a my Harland faction- seven thousand- I guess it was inDediti them in two groups, giving half of them or we got free, false capturesand the other one hollybourn. They found a better survive, lower incidents,rates of Corne rein, Fortin and a low death rate, and so on. So by adding upthis, I was gradually acknowledged. Now, there's no doubt that long changed homewe or free Fay asesen wedge as a sensor component of human, dire and Huniaessential in biological functions of merits, in our block and in our buty. But of course there can be discussionsas through whether supplementation will be to this on that effect on health, like what you hear so far make sure younever miss a show by clicking the subscribe. But now this podcast is madepossible by listeners like you. Thank you for your support. Now back to theshow Dr Diver, I'm eager to hear about yourexperiences in Greenland, but before that I'd like to take a moment toclarify something in the Western world today there is resistance torecommending fish oil supplements because of the perception they causebleeding. Now we just heard part of your discovery was that a mega three'sincrease bleeding tendency. Could you say more about this really to help ourlisteners understand and do you think people should avoid taking fish oil asnutritional supplements because of this perception? Yeah. Thank you for this question,which is, of course, a very essential question, because if we just boil itdown, yes, the inoits at that did had a bleeding tendency, but we Americans andLeenane have a frombodied tendency were...

...not time from bleeding realm fromtrombos s white. I am from my kind of heart attack. That's what we are dyingfrom. That's a major course of death in American and then went to and thatcould be bought down to bore about a person that are exposed to an operation.Should he she stop taking fish in supplements because of an increasedbleeding brisk and that's a genuine question. Tres and it has been raised in the scientificliterature and I think I'll in that respect, focus on two works. First,this a paper in Secula Ion the American had associations General Medical Journal where they wentinto the data from a major trial, the over a trial, including nearly two sandpersons. I think it was fifteen hundred or something and- and they found thatif these there were some patients who, before operations, took eight to tengram official to day and also did that after the operation- and there wereother who did not take fish oil before ration and did not take it after theoperation. So they compared these two groups. Whether the Fisher group had amore breeding tendency or breeding complications or had an higher need fortransfusion, and they found quite the opposite. The risk of bleeding during operationmissed measured on how much plot they lost to a ration, which we way byweighing the same servants and the extract on starting out from theoration field was your low in those on ficial than those neat that didn't takefish oil and when they measured after the operation procedure and when thepatient was was sent on the number of transfusions, these patient God. Thegroup that took fish oil before and during an after OBRAS had a lowerintake or have a low consumption of bloodtransfusions. So it was quite the opposite and they concluded they had. There were no need for stop fish ofintake before enjoying operations. This has been a basis of a further farlarger meter and Elyses of the this paper here, which came near at the sametime studying a fifty two reported studies on bleeding risk during anafter operation compared to groups taking fish on or two groups who didnot take fishal before and of Terain, and their conclusion was no need fordiscarnation of fish or supplementation prior to after surgery, because thebleeding risk was equal to a lower than those who did not take fish or so evenif an intake official does shift the hemostatic balance from Trombonitowards none from body situations, the increased risk of bleeding due tophysical damages in football or during OperationArden birth has no extra risk on bleeding. Actually what they found wasquite the opposite, which maybe has explanations due to the antiinflammatory effect of ficial and...

...components that damp in theinflammatory component in the wounds and thereby all so damn, but thebleeding risk so no need for concern. Well, thank you for clarifying thisimportant point and going back to your greenland experience. Could you tell usa little more about the environment and the testing you did on your journeysyeah, so y'all we lived along with the ESQUIMO and we ate their food. I had raw sing, lamorant and Rob Brober,and sometimes we vile a bit of a kidney and yeah, but but I lived heavily with itand sometimes if we may happen eat that,because it tastes good and you should remember you're not standing on thesanded beach in Egypt with the Dead Sea and the flies is a running here. You'restanding in the beach, hopefully in summer time, where the temperature canbe around the freezing point and the cold board is slaking in or on thebeach and he's cutting up a new kill sea at the blood is frol and it smellswell and the dogs get a stone in their back if they come to near, and then wecut out some fresh well smelling thing and I live from it and it tastes well,and I've been a doing so for centuries, and we did it for a few months, five orsix times and we enjoyed it, and you should remember a young man having thisexperience. Science is good, but for a young doctor, being twenty nine orthirty, two experience on the dog late in shooting scenes and fishing redfish in whatever is great fun. So, besides the great front from thescience expeditions were a great front you. How many times did you take thatjourney to Greenland? I six times a to months at a time. So as we sit here in two thousand andtwenty one, what would you like the listeners toknow today about that research and about nutritional health, as it relatedall the way back to that journey of yours fifty years ago? A message is that, unfortunately, ourwestern type diet, especially that one you idion, the United States, is veryhigh in the Orgust Faluas, which is okay, but they low in the long changeof Garizo. The balance has to be shifted or something, and what isessential is that you cannot do that by cutting down on one thing, but only byadding up on the other, because you know get more of one thing by cuttingdown on another thing, so this balance Port of you is not my favorite, butthere is a balance function between e, six, O and free, and we should increasethe Ongar site of our ass in our diet. But if I should boil down what my workhas really meant, aside from having nutrition to focus on that and theParentes, we probably saw the first papers in the beginning. On thousand aD. Seventy Sad, I started adding up how many that came, and I was heavy related,and now they are four papers in the literature to day that there are fiftythousand or something. So it has really meant something. But if I should ask-and the area where I feel really we...

...touch in something- is that thedeficiency of lochindorb in females might give rise to a Cerbera, I will not say a deficiency,but in the new words, however, it has been shown in rather many studies that pregnancy outcome is improved by addinga decent amount of long chander, with our free fedes to the mother's stayedduring pregnancy and during the Latat, and if we can act to the brains of anew watch, I think we are really dealing with something that is fantastic and Dr Diabe. I'm soappreciate, if you taking the time today to walk our listeners throughthat. I can't thank you enough. I know how busyyou are, and I know your time is of demand and just being part of theprogram. I'm really appreciative of that. Okay, you is fame playsure toenjoy, and I love telling the story a yeah, that's my life! Thank you and good. Bye have an icedays. You hear I'll go for a glass of right. Mind Reaction, Dr Diber. Thank you. So very much forbeing with this today. It's an honor for me to have the father of a megathrees on this program and thank you so much listeners for joining us today andis always be healthy, be well and fight the good fight. This has been the science and the storybehind Omega Three. Thanks to our sponsor wily companies, you can findthem and more information about our show at Wiley Cocom, a podcast. If youenjoy today's episode, don't forget to subscribe. Wherevero, you get yourpodcasts thanks for listening and we'll catch you next time any statements on this podcast or theopinion of the scientific guests and or author, and have not yet been evaluatedby the FDA. The information we may provide to you is design foreducational purposes only as not intended to be a substitute forinformed medical advice or care. This information should not be used todiagnose, treat or prevent any health issues or conditions without consultinga health care professional. If you are experiencing a health, as you areconditioning, we suggest you consult with your health care, professional.

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